Targeting oncogenes in advanced melanoma

Targeting oncogenes in advanced melanoma

The ability to target oncogenes in malignancies such as CML, GIST, APML and ERBB2-positive breast cancer has revolutionized the management of those diseases. Interesting over 70% of melanomas contain genomic amplification or mutations in one of the oncogenes BRAF, NRAS, KIT, CCND1 or CDK4 that may induce an oncogene addicted state. Inhibition of BRAF with Vemurafenib or GSK2118436 in BRAF-mutan...

Targeting KIT for Treatment Of Advanced Melanoma

This is a remarkable time for melanoma research and treatment. Before this year, approved agents available for the treatment of metastatic melanoma were limited to dacarbazine (DTIC) and interleukin-2 (IL-2), with benefits achieved in only a small minority of patients treated with either drug. In 2011, however, two new agents, ipilimumab (YervoyTM) and vemurafenib (ZelborafTM), were approved, w...

Targeting c-Met in melanoma

Targeting the Proteasome in Melanoma

Malignant melanoma, once disseminated, is a malignant neoplasm extremely resistant to conventional anticancer treatment, such as chemo or radiation therapies. Therefore, new therapeutic strategies are under investigation as, for instance, immunotherapy, gene therapy or so called targeted therapy. Proteasome appears as one of these new possible targets. The ubiquitin proteasome pathway is a comp...

Targeting metastatic melanoma.

PURPOSE New medications and combination treatment strategies for patients with metastatic melanoma are discussed. SUMMARY Bcl-2 is an inhibitor of apoptosis that is overexpressed in approximately 80% of melanoma cell lines and is believed to contribute to the development of resistance to cytotoxic chemotherapy in patients with melanoma. Oblimersen, an antisense oligonucleotide that stops the ...